Why Non-Volatile Residue Detection in Purified Water is Critical for Regulated Industries

Significance of Non-Volatile Residue Detection in Purified Water

Purified water is a crucial raw material in industries like pharmaceuticals, biotechnology, and electronics manufacturing.



Non-volatile residues are non-evaporating substances (like inorganic salts, organic matter, microbial byproducts) that remain after evaporation at a specific temperature (e.g., 105℃).

Detecting Non-Volatile Evaporation residues is important for

  • Regulatory Compliance: Meeting limits set by pharmacopoeias (e.g., For "Purified Water in Containers", the Ph. Eur. European Pharmacopoeia has a requirement for "Residue on Evaporation" of ≤0.001%).
  • Process Stability and Risk Control: Accumulation of residues can alter water conductivity and pH, affect process consistency, clog equipment, corrode metal parts, or interfere with reactions.
  • Drug Production Safety: Heavy metals (e.g., lead, mercury) or endotoxins in residues can contaminate drugs, causing allergic reactions or toxicity in patients.
  • Electronics Manufacturing Quality: Residual ions can lead to short circuits or performance degradation in semiconductor devices.

Detection Methods for Non-Volatile Residue in Purified Water

The core procedures of the Non-Volatile Residue test are evaporation-drying-weighing.

The common gravimetric method (Pharmacopoeia) involves taking 100mL of purified water, evaporating it in a constant-weight evaporating dish on a water bath, drying it at 105℃ to constant weight, and calculating the mass difference of the residue.

Non-Volatile Residue Testing Instrument

While the evaporation residue test is a widely employed method, fully automated systems for its execution are a relatively recent innovation. Labthink C840H Integrated Evaporation Residue Test System is a leading example of these cutting-edge solutions.

This system is based on the gravimetric principle and designed conforming to relevant testing standards and Chinese, US, European Pharmacopoeia.

It can test evaporation residues for chemical reagents, non-volatile matter for pharmaceutical packaging materials (films, bags, bottles, etc.) and purified water, and overall migration for food packaging materials.

How C840H works

It integrates the traditional steps of evaporation, drying, and weighing to constant weight at room temperature into one system.

The C840H features 25 test cups, a precise electronic balance (0.05mg repeatability) with a visible weighing window for traceability, and a "dual-chamber " design (evaporation and weighing chambers are separate) to protect the balance from high temperature and humidity.

This system reduces manual operations, minimizes human error, enhances data reproducibility, improves test safety and lowers the future cost of maintenance.

 


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