Labthink Knowledge

Loss on Drying (LOD) is one of the most widely used analytical methods for determining the loss of volatile substances in pharmaceutical, food, and chemical products. By measuring the difference in sample weight before and after controlled drying, LOD testing provides valuable information about product characteristics, quality consistency, and compliance with industry requirements. In pharmaceutical manufacturing, Loss on Drying is an important quality control parameter for raw materials, intermediates, and finished products. The content of moisture and other volatile components may directly influence product stability, processing performance, and storage conditions. For decades, laboratories have relied on traditional manual LOD procedures. However, conventional workflows often involve multiple steps, including sample preparation, initial weighing, drying, cooling, repeated weighing, and manual calculation. These operations require significant operator involvement and may introduce v...

In the high-speed world of Vertical Form Fill Seal (VFFS) packaging, the difference between a perfect production run and a morning of wasted film often comes down to a single invisible variable: the Coefficient of Friction (COF) . Whether your film is stuttering over the forming collar or slipping through the pull belts, understanding the interplay between static and kinetic friction is the key to maintaining machine uptime. Section 1: Static vs. Kinetic COF in Packaging To troubleshoot machine failures, we must first distinguish between the two phases of friction. Static COF (The Starting Force): This is the peak force required to initiate movement between two resting surfaces. In VFFS, this occurs when a heavy film roll begins to unwind after a pause, or when the film rests against the metal forming collar before the pull cycle begins. Kinetic COF (The Sliding Force): Also known as dynamic friction, this is the continuous force required to maintain movement at a steady, constant sp...

  In the modern packaging material landscape, aluminum foil remains a cornerstone for preserving product integrity. From the pharmaceutical industry to the food industry, this thin metal sheet provides a level of protection that most polymers cannot match. As global markets shift toward extended shelf lives and stricter safety standards in 2026,understanding the performance and quality control of foil-based solutions is more critical than ever. Advantages of Aluminum Foil Packaging The widespread adoption of aluminum foil is driven by its unique physical and chemical properties: Total Barrier Protection: Aluminum foil acts as a "dead-fold" barrier, providing nearly zero oxygen transmission rate (OTR) and total resistance to light and odors. Moisture Barrier: It is the ultimate moisture barrier, effectively blocking water vapor to prevent spoilage, hydrolysis, and rancidity in sensitive products like fishery items or semi-moist snacks. Thermal Stability: It is non-flammable...

  Residue on Ignition (ROI) is a widely used analytical method to determine the amount of inorganic impurities in a material. It is commonly applied in pharmaceutical, chemical, and food-related industries where material purity is critical. In simple terms, ROI measures the non-combustible residue remaining after a sample is subjected to high-temperature ignition. Why ROI Matters Residue on Ignition is widely used for: Pharmaceutical quality control (e.g., USP <281>) Raw material purity evaluation Contamination monitoring Process consistency verification It provides a reliable indicator of total inorganic residue, even though it does not identify specific components. The Principle: Loss on Ignition ROI is based on gravimetric analysis , also known as loss-on-ignition . When a sample is heated in a muffle furnace (typically 500°C–800°C ): Organic substances decompose and volatilize Carbon-based materials are burned off Inorganic residues remain as ash The remaining residue re...

Residue on Ignition (ROI) testing is a critical analytical method used in the pharmaceutical, food, chemical, and advanced materials industries to determine inorganic impurities and product purity. Traditionally, this test has relied heavily on manual operations, making the process time-consuming, labor-intensive, and susceptible to operator variability. Leveraging more than 14 years of dedicated research and development, Labthink has introduced the C860 Integrated Residue on Ignition Testing System , a fully automated solution designed to streamline the entire testing workflow. From weighing and acid addition to ignition, cooling, reweighing, and constant-weight determination, the C860MH automates every critical step, significantly improving laboratory efficiency and data reliability. At the heart of the system is an intelligent robotic handling mechanism that automatically transfers crucibles between the analytical balance and the muffle furnace. This eliminates manual handling, red...

  When consumers purchase a bottle of water, a yogurt cup, or a ready-to-eat meal, they rarely think about the packaging itself. Yet behind every food package lies a critical question: Can substances from the packaging migrate into the food? This question sits at the heart of food contact material (FCM) regulations worldwide and has become increasingly important as packaging structures grow more sophisticated and regulatory requirements continue to evolve. Understanding Migration in Food Packaging Plastic food packaging is far more than a simple polymer. Modern packaging materials often contain a combination of: Monomers Additives Stabilizers Processing aids Plasticizers Antioxidants Colorants and coatings These substances are used to improve performance, durability, appearance, and processing efficiency. However, under certain conditions, some of these substances may transfer from the packaging into food. This phenomenon is known as migration . Migration does not automatically im...